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Our latest research
DIFFERENT LIFELONG BEHAVIOURS OF CH SUBTYPES
DIFFERENT DRIVER GENES PROMOTE CLONAL HAEMATOPOIESIS (CH) AT DIFFERENT TIMES IN LIFE. CLONES DRIVEN BY MUTATIONS IN DNMT3A EXPAND IN YOUNG AND THOSE DRIVEN BY MUTATIONS IN SPLICING GENES IN OLD PEOPLE.
CHECK THIS AND MORE OUT HERE:
https://www.nature.com/articles/s41586-022-04785-z
THE INHERITED GENOME AND CLONAL HAEMATOPOIESIS
OUR LATEST STUDY OF MORE THAN 200,000 PEOPLE REVEALS THAT INHERITED GENETIC VARIATIONS CAN INCREASE OR DECREASE THE LIKELIHOOD OF DEVELOPING CLONAL HAEMATOPOIESIS. WE ALSO FIND THAT SMOKING HAS A CAUSATIVE ROLE IN CH DEVELOPMENT AND THAT CH IS ASSOCIATED WITH AN INCREASED RISK OF ABNORMAL HEART RHYTHMS. SEE HERE:
https://www.medrxiv.org/content/10.1101/2022.01.06.22268846v1
NPM1 MUTATIONS: RARE BUT OMINOUS
WE SEARCHED FOR MUTATIONS IN THE NPM1 GENE IN 220,00 PEOPLE. WE FOUND IT IN ONLY TWO. BOTH DEVELOPED ACUTE MYELOID LEUKAEMIA WITHIN 5-6 MONTHS. CAN WE PREVENT THIS FROM HAPPENING IN FUTURE?
https://pubmed.ncbi.nlm.nih.gov/34920452/