SELECTED PUBLICATIONS

McLoughlin MA et al. Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis. Nat Genet. 57:2215-2225 (2025).

Gozdecka M et al. Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis. Nature 642:431-441 (2025).

Damaskou A et al. Posttranscriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in NPM1-mutant AML. Blood 146:1239-1252. (2025).

Wen S et al. Comparative analysis of the Mexico City Prospective Study and the UK Biobank identifies ancestry-specific effects on clonal hematopoiesis. Nat Genet 57:572-582 (2025).

Gu M et al. Multiparameter prediction of myeloid neoplasia risk. Nat Genet.1523-30 (2023).

Cheloor Kovilakam S et al. Prevalence and significance of DDX41 gene variants in the general population. Blood (2023).

Kar SP et al. Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis. Nat Genet 54, 1155-1166 (2022).

Fabre MA et al. The longitudinal dynamics and natural history of clonal haematopoiesis. Nature 606, 335-342 (2022).

Yankova E et al. Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature 593, 597-601 (2021).

Uckelmann HJ et al. Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia. Science 367:6477 586-590 (2020)

Gozdecka M et al. UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs. Nat Genet 50, 883-894 (2018).

Abelson S et al. Prediction of acute myeloid leukaemia risk in healthy individuals. Nature 559, 400-404 (2018).

Barbieri I et al. Promoter-bound METTL3 maintains myeloid leukaemia by m(6)A-dependent translation control. Nature 552, 126-131 (2017).

Tzelepis K et al. A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia. Cell Rep 17, 1193-1205 (2016).

McKerrell T et al. Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis. Cell Rep 10, 1239-1245 (2015).

 Vassiliou GS et al. Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Nat Genet 43, 470-475 (2011).